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Proton and carbon chemical shift assignment and dynamic investigation of the macrolide antibiotic tylosin
Author(s) -
Rossi Claudio,
Donati Alessandro,
Picchi Maria Pia,
Sansoni Maria Rosaria,
Corbini Gianfranco,
Corti Piero
Publication year - 1992
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260301007
Subject(s) - tylosin , chemistry , protonation , moiety , molecular dynamics , chemical shift , carbon fibers , proton , stereochemistry , computational chemistry , nuclear magnetic resonance , antibiotics , organic chemistry , ion , biochemistry , materials science , physics , quantum mechanics , composite number , composite material
The NMR spectral properties of the antibiotic tylosin were investigated. DQ‐COSY and HETCOR two‐dimensional spectra were used for the assignment of both the proton and protonated carbon signals. Selective (H)C‐NOE, were proposed for the controversial quaternary carbon assignments. The analysis of molecular motion in solution based on carbon spin–lattice relaxation rates shows that tylosin exhibits dynamics that are typical of each molecular moiety. A higher degree of free motion is observed with increasing distance from the macrolide nucleus.