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Phenindamine and its analogues and precursors: NMR evidence of structure and configuration
Author(s) -
Casy Alan F.,
Hussain Rohannah B.,
Upton Christopher
Publication year - 1992
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260300708
Subject(s) - chemistry , stereochemistry , proton nmr , nmr spectra database , two dimensional nuclear magnetic resonance spectroscopy , spectral line , computational chemistry , physics , astronomy
The 1 H and 13 C NMR spectra of analogues of the antihistaminie agent phenindamine and its precursors are interpreted in terms of structure and geometry. Points of interest are the conformations of 4‐piperidinol and dihydro‐1‐pyrindene(diene) intermediates, and the configuration of the hexahydro analogue of phenindamine and its corresponding product of equilibration. Results of an antihistamine evaluation test are presented.