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Region‐selective inverse‐detected long‐range heteronuclear chemical shift correlation using shaped pulses
Author(s) -
Crouch Ronald C.,
Spitzer Timothy D.,
Martin Gary E.
Publication year - 1992
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260300705
Subject(s) - heteronuclear molecule , chemistry , heteronuclear single quantum coherence spectroscopy , inverse , range (aeronautics) , two dimensional nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , correlation , molecular physics , nuclear magnetic resonance spectroscopy , stereochemistry , physics , materials science , geometry , mathematics , composite material
F 1 region‐selected variants of the HMBC experiment were compared and evaluated. In particular, a significant advantage was demonstrated for an E‐BURP‐2 pulse over a Gaussian 270° pulse for region‐selected applications. The Gaussian 270° pulse would still, however, be the preferred pulse for use in single‐resonance, on‐resonance selective excitation. Data are presented from NMR spectrometers both equipped and not equipped with programmable pulse modulators (waveform generators). Pulse evaluations were performed using the simple heteroaromatic alkaloid quindoline; application of the technique to the important immunosuppressive cyclic peptide cyclosporin‐A is also presented and discussed.