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1 H NMR model studies of amphotericin B: Comparison of x‐ray and NMR stereochemical data
Author(s) -
Sowiński Pawel,
Pawlak Jan,
Borowski Edward,
Gariboldi Pierluigi
Publication year - 1992
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260300402
Subject(s) - chemistry , amphotericin b , stereochemistry , nuclear magnetic resonance spectroscopy , two dimensional nuclear magnetic resonance spectroscopy , proton nmr , nmr spectra database , chemical shift , spectral line , crystallography , antifungal , microbiology and biotechnology , astronomy , biology , physics
1 H NMR data for amphotericin B methoxycarbonylmethylamide extracted from DQF‐COSY, ROESY and 1D spectra were compared with x‐ray data for amphotericin B. The conformation of amphotericin B in solution was identical with that found by x‐ray analysis in the solid state. Most of the relay artifacts observed in the ROESY spectrum were recognized, and their pathways of formation were assigned.