1 H NMR studies of human urine: Urinary elimination of the anticancer drug carboplatin | Zendy

Ranford John D. | Zendy; Sadler Peter J. | Zendy; Balmanno Katherine | Zendy; Newell David R. | Zendy

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1 H NMR studies of human urine: Urinary elimination of the anticancer drug carboplatin

Author(s) -

Ranford John D.,

Sadler Peter J.,

Balmanno Katherine,

Newell David R.

Publication year - 1991

Publication title -

magnetic resonance in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 72

eISSN - 1097-458X

pISSN - 0749-1581

DOI - 10.1002/mrc.1260291321

Subject(s) - carboplatin , chemistry , urine , drug , anticancer drug , nuclear magnetic resonance spectroscopy , creatinine , excretion , pharmacology , stereochemistry , chemotherapy , biochemistry , medicine , cisplatin

Samples of urine from a patient obtained before and after treatment with 300 mg of the anticancer drug [Pt(II)(NH 3 )2(CBDCA)] (carboplatin, “Paraplatin”, where CBCDA is 1,1‐dicarboxycyclobutane) have been analysed using 500 MHz 1D and 2D 1 H NMR spectroscopy. Peaks for the intact drug and the free ligand CBDCA have been assigned and are present in a mol ratio of ca. 5:1. Only about one half of the total Pt in the sample was present as intact drug. Relative to creatinine and citrate, the excretion of hippurate increased by a factor of ca. 4 after drug treatment. This work suggests that NMR spectroscopy can play a valuable rǒle in studies of carboplatin metabolism.

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