Synthesis and steric structure of  cis ‐ and  trans ‐alicycle‐fused dihydrothiazepines | Zendy

Sohár P. | Zendy; Újszászy K. | Zendy; Szabó J. | Zendy; Simon L. | Zendy; Talpas G. S. | Zendy; Fodor L. | Zendy; Bernáth G. | Zendy

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Synthesis and steric structure of cis ‐ and trans ‐alicycle‐fused dihydrothiazepines

Author(s) -

Sohár P.,

Újszászy K.,

Szabó J.,

Simon L.,

Talpas G. S.,

Fodor L.,

Bernáth G.

Publication year - 1991

Publication title -

magnetic resonance in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 72

eISSN - 1097-458X

pISSN - 0749-1581

DOI - 10.1002/mrc.1260290911

Subject(s) - chemistry , steric effects , cyclohexane , ring (chemistry) , dept , nuclear magnetic resonance spectroscopy , stereochemistry , organic chemistry

β‐Lactam‐condensed saturated thiaazabicycles underwent ring transformation to give a new type of alicycle‐fused 3‐phenyl‐2‐methoxycarbonyl‐4,5‐dihydro‐1,4‐thiazepine. Oxidation of the cis and trans cyclohexane derivatives with perbenzoic acid furnished sulphones. The configurations and conformations of the new compounds were confirmed by 1 H and 13 C NMR spectroscopy, making use of DR, DNOE, DEPT and 2D HSC measurements.

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