Premium
Synthesis and steric structure of cis ‐ and trans ‐alicycle‐fused dihydrothiazepines
Author(s) -
Sohár P.,
Újszászy K.,
Szabó J.,
Simon L.,
Talpas G. S.,
Fodor L.,
Bernáth G.
Publication year - 1991
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260290911
Subject(s) - chemistry , steric effects , cyclohexane , ring (chemistry) , dept , nuclear magnetic resonance spectroscopy , stereochemistry , organic chemistry
β‐Lactam‐condensed saturated thiaazabicycles underwent ring transformation to give a new type of alicycle‐fused 3‐phenyl‐2‐methoxycarbonyl‐4,5‐dihydro‐1,4‐thiazepine. Oxidation of the cis and trans cyclohexane derivatives with perbenzoic acid furnished sulphones. The configurations and conformations of the new compounds were confirmed by 1 H and 13 C NMR spectroscopy, making use of DR, DNOE, DEPT and 2D HSC measurements.