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Inclusion complexes between β‐cyclodextrin and β‐benzyloxy‐α‐propionic derivatives of paramagnetic DOTA‐ and DPTA‐Gd(III) complexes
Author(s) -
Aime Silvio,
Botta Mauro,
Panero Maurizio,
Grandi Maurizio,
Uggeri Fulvio
Publication year - 1991
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260290910
Subject(s) - chemistry , dota , cyclodextrin , relaxation (psychology) , solvent , titration , paramagnetism , stability constants of complexes , proton nmr , inclusion (mineral) , equilibrium constant , crystallography , stereochemistry , aqueous solution , medicinal chemistry , chelation , organic chemistry , psychology , social psychology , physics , mineralogy , quantum mechanics
The addition of β‐cyclodextrin to a solution containing β‐benzyloxy‐α‐propionic‐substituted DOTA‐ and DTPA‐Gd(III) complexes leads to the formation of inclusion compounds whose equilibrium constants have been determined by NMR titrations. The main effect associated with the formation of this ‘host‐uest’ interaction is a marked elongation of the molecular reorientational time, τ r , which in turn results in increased solvent proton relaxation rates.