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1 H and 13 C NMR analyses of amiodarone, desethylamiodarone and desoxoamiodarone
Author(s) -
Ribeiro Anthony A.,
Jendrasiak Gordon L.
Publication year - 1991
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260290513
Subject(s) - chemistry , homonuclear molecule , amiodarone , nuclear magnetic resonance spectroscopy , nmr spectra database , two dimensional nuclear magnetic resonance spectroscopy , molecule , chemical shift , stereochemistry , nuclear magnetic resonance , spectral line , organic chemistry , medicine , physics , astronomy , atrial fibrillation , cardiology
The 1 H and 13 C NMR spectra of amiodarone, a potent cardiac antiarrhythmic agent, desethylamiodarone, the main metabolite of amiodarone and desoxoamiodarone, a less toxic form of amiodarone, were assigned using a combination of NMR techniques. Methods applied include 1 H‐ 1 H COSY, homonuclear Hartmann–Hahn relayed spectroscopy (HOHAHA), broadband decoupled 1 H– 13 C chemical shift correlation, long‐range 1 H– 13 C chemical shift correlation and selective INEPT. This combination of NMR experiments has completed a molecular walk along the covalent framework of the cardiac drug molecules, and removed ambiguities in their 1 H and 13 C NMR assignments.