Premium
13 C NMR spectra of multifunctional bile acid derivatives
Author(s) -
Blossey Erich C.,
Ford Warren T.,
Periyasamy Mookkan
Publication year - 1991
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260290218
Subject(s) - chemistry , substituent , dept , carbon 13 nmr , stereochemistry , bile acid , two dimensional nuclear magnetic resonance spectroscopy , biochemistry
Carbon‐13 NMR signals were assigned to a set of methyl 5β‐cholanoates having multiple functional groups, including hydroxy, carbonyl and acetoxy groups. Assignments were based on empirical chemical shift rules for α‐, β‐ and γ‐substituent effects, direct spectral comparison with compounds of similar structure, DEPT and 2D‐HETCOR. Use of β‐substituent effects permitted the assignment of structural changes at positions 3, 7 and 12 of the steroidal nucleus.