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Structural elucidation of germine esters isolated from Veratrum nigrum L. Total assignment of 1 H and 13 C nuclear magnetic resonances by two‐dimensional NMR techniques
Author(s) -
Han Xiuwen,
Grossmann Peter,
Rüegger Heinz
Publication year - 1991
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260290203
Subject(s) - homonuclear molecule , chemistry , heteronuclear molecule , nuclear magnetic resonance spectroscopy , two dimensional nuclear magnetic resonance spectroscopy , spectroscopy , stereochemistry , spectral line , nuclear magnetic resonance , crystallography , molecule , physics , organic chemistry , quantum mechanics , astronomy
Abstract The application of two‐dimensional phase‐sensitive COSY, ROESY and 13 C– 1 H shift correlation spectroscopy in the structural elucidation and stereochemical assignment of the steroidal alkaloids 15‐(2‐methylbutyryl)germine, 3‐(2‐hydroxy‐2‐methylbutyryl)‐15‐(2‐methylbutyryl)germine and 16‐(2‐methylbutyryl)germine is reported. It is shown that two‐dimensional 13 C– 1 H heteronuclear long‐range correlation spectroscopy is an invaluable method for the stereochemical assignment of proton resonances which overlap in 1 H NMR and homonuclear correlation spectra.