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Conformational analysis of methyl phenyl sulphoxides containing fluorine substituents in the phenyl ring based on 1 H, 13 C and 17 O NMR chemical shifts and long‐range n J (HF) and n J (CF) coupling constants
Author(s) -
Benassi Rois,
Folli Ugo,
Iarossi Dario,
Mucci Adele,
Schenetti Luisa,
Taddei Ferdinando
Publication year - 1990
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260280809
Subject(s) - chemistry , conformational isomerism , substituent , ring (chemistry) , chemical shift , crystallography , coupling constant , methyl group , fluorine , molecule , molecular geometry , stereochemistry , computational chemistry , bond length , group (periodic table) , crystal structure , organic chemistry , physics , particle physics
The preferred conformations of the methylsulphinyl group in a number of phenyl methyl sulphoxides substituted in the phenyl ring with one, two or three fluorine atoms have been studied by employing a multinuclear NMR approach. From the 1 H, 13 C and 17 O chemical shifts of the methylsulphinyl group, and the torsional angles obtained either from MO calculations or experimental determinations for a number of the compounds, empirical correlations have been derived which enabled us to extract the preferred orientation of the SO bond or of the methyl group relative to the phenyl ring in all the molecules examined. For a limited number of the compounds, the structure of the preferred conformer is satisfactorily close to the solid‐state structure found in an independent study carried out with x‐ray diffraction. The twist of the SO bond relative to the phenyl ring changes as a function of the number of ortho substituents, being highest when two substituents are present. The lowest twist, torsional angle nearly zero, was found in ortho ‐monosubstituted compounds and the SO bond is oriented towards the opposite side with respect to the substituent. Analyses were also carried out of the conformational dependence of long‐range n J (HF) and n J (CF) coupling constants, where the first nucleus in the parentheses refers to the methylsulphinyl group. The behaviour of these coupling constants as a function of internal rotation around the exocyclic CS bond was derived from semi‐empirical INDO MO FPT calculations, and scaled interpolating equations were derived in order to reproduce the experimental results. It thus emerges that 5 J (HF), 4 J (CF), 5 J (CF) and 6 J (CF) are conformationally dependent and show, experimentally, significant changes. These parameters can be usefully employed for the conformational analysis of methyl phenyl sulphoxides.