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1 H and 13 C NMR studies of the protonation of isomeric methoxysulmazole analogues
Author(s) -
Lindon J. C.,
Williams J. M.,
Barraclough P.,
King W. R.,
Nobbs M. S.
Publication year - 1990
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260280703
Subject(s) - chemistry , protonation , aryl , nitrogen , medicinal chemistry , derivative (finance) , nuclear magnetic resonance spectroscopy , stereochemistry , organic chemistry , ion , alkyl , financial economics , economics
The major protonation sites of six cardiotonic isomeric 2‐aryl‐ n ‐methoxy‐1 H ‐imidazo[4,5‐ b ]‐ and ‐[4,5‐ c ]‐pyridines (n = 4–7) were determined by 1 H and 13 C NMR methods. All the 1 H ‐imidazo[4,5‐c]pyridines and the 7‐methoxy derivative of sulmazole were found to protonate at the pyridyl nitrogen. Protonation occurred at the imidazo nitrogen, however, for the 5‐ and 6‐methoxy derivatives of sulmazole.