Premium
Electron paramagnetic resonance study of the complex formed between copper and 1‐[2( S )‐3‐mercapto‐2‐methylpropionyl]‐ L ‐proline (Captopril) in solid and aqueous solution
Author(s) -
Evans Jeffrey C.,
Morris Caroline R.,
Rees Sian B.,
Rowlands Christopher C.,
Williams David R.
Publication year - 1989
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260270306
Subject(s) - electron paramagnetic resonance , chemistry , copper , aqueous solution , ligand (biochemistry) , inorganic chemistry , crystallography , nuclear magnetic resonance , organic chemistry , receptor , biochemistry , physics
EPR spectroscopy was used to elucidate the nature of the interaction between copper and the antihypertensive agent 1‐[2(S)‐3‐mercapto‐2‐methylpropionyl]‐L‐proline (Captopril) in both solid and aqueous solutions. The EPR spectra indicate that binding to copper(II) occurs via the ligand oxygens rather than the thiol moieties, and that the EPR‐detectable copper is greatly reduced on complexation. The EPR parameters for the solid copper(II) complexes are in the range g ∥ = 2.374−2.386, g ⟂ = 2.076−2.086 and A ∥ Cu= 13.5 mT, and the parameters for the aqueous solutions are g iso = 2.107−2.129 and A ∥ Cu= 7.1−8.6 mT.