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Complete spectral assignments of cevadine and veratridine by 2D NMR techniques
Author(s) -
Krishnamurthy V. V.,
Casida John E.
Publication year - 1988
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260261109
Subject(s) - chemistry , veratridine , proton , two dimensional nuclear magnetic resonance spectroscopy , spectral line , analytical chemistry (journal) , proton nmr , nuclear magnetic resonance , stereochemistry , sodium , organic chemistry , physics , nuclear physics , sodium channel , astronomy
The long‐range CH correlation NMR experiment (with decoupling of modulation of intensities due to one‐bond couplings during refocusing) and the double quantum coherence correlation spectroscopy (DQCOSY) experiment were used, together with the standard one‐bond CH correlation and COSY spectra, for complete 13 C and 1 H spectral peak assignments of veratrine (a 2:1 mixture of cevadine and veratridine). The long‐range CH correlation experiment determined the long‐range CH connectivity network, thus indirectly providing carbon–carbon connectivity. The DQCOSY experiment proved to be a complementary technique to the standard COSY experiment in unraveling and/or confirming proton–proton connectivities in this highly crowded proton spectrum.