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Evaluation of pulse sequences combining 13 C‐ 1 H shift correlation and heteronuclear J spectroscopy with full 1 H‐ 1 H decoupling
Author(s) -
PerpickDumont Marion,
Reynolds William F.,
Enríquez Raúl G.
Publication year - 1988
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260261013
Subject(s) - heteronuclear molecule , chemistry , chemical shift , spectroscopy , carbon 13 , analytical chemistry (journal) , pulse sequence , molecule , nuclear magnetic resonance spectroscopy , atomic physics , nuclear magnetic resonance , stereochemistry , physics , nuclear physics , organic chemistry , quantum mechanics , chromatography
Three different two‐dimensional 13 C‐ 1 H shift‐correlation sequences which detect 1 H chemical shifts and one bond 13 C‐ 1 H[J(CH)] couplings in f 1 with full 1 H‐ 1 H decoupling are described and evaluated. They are particularly useful for detecting small differences in 1 J(CH) for non‐equivalent methlene groups in natural products and other complex organic molecules. The best of the three allows determination of 1 J(CH) and 1 H chemical shifts to a precision better than 1 Hz, with sensitivity comparable to previous shift‐correlation and J‐resolved pulse sequences. 1 J(CH) Values for a typical alkaloid suggest that these parameters are a useful probe of conformational, electronic and ring size effects in natural products.