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Application of cyclodextrins to chiral analysis by 1 H NMR spectroscopy
Author(s) -
Casy A. F.,
Mercer A. D.
Publication year - 1988
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260260908
Subject(s) - chemistry , nuclear magnetic resonance spectroscopy , inclusion (mineral) , inclusion compound , spectroscopy , carbon 13 nmr , computational chemistry , stereochemistry , organic chemistry , cyclodextrin , mineralogy , physics , quantum mechanics
The influence of inclusion complex formation between cyclodextrins (chiefly the β‐polymer) and a variety of chiral antihistaminic and analgesic agents on the 1 H NMR features of both guest and host partners is reported. In many cases equivalent protons of antipodes give resonances which differ in chemical shift after inclusion, and the potential value of the data to chiral analysis and to elucidation of the structures of the inclusion complexes is demonstrated.