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Repeatability and reproducibility of site‐specific isotope ratios in quantitative 2 H NMR
Author(s) -
Guillou C.,
Trierweiler M.,
Martin G. J.
Publication year - 1988
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260260611
Subject(s) - repeatability , reproducibility , chemistry , analytical chemistry (journal) , calibration , spectrometer , confidence interval , statistical inference , chromatography , statistics , mathematics , physics , quantum mechanics
The repeatability and reproducibility of quantitative deuterium NMR at the natural abundance have been determined according to the ISO norms in a collaborative study This study was organized by the Community Bureau of Reference, EEC (Bruxelles). The list of the participants is given at the end. involving 16 spectrometers. A repeatability of better than 0.8% and a confidence interval of 0.25% have been determined from the results obtained in the 15 different European laboratories that participated in the collaborative study. The reproducibility of the measurements carried out on very different NMR systems is of the order of 2–3%, but this can be improved to 1% with more homogeneous spectrometer systems. The influence of the spectrometer performances on the precision of the quantitative data has been analysed in terms of statistical inference, variance analysis and multidimensional factorial representation. The results indicate the advantages of using highly automated procedures to decrease the random error in the measurement.