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Structural and conformational analysis by 1 H NMR and 13 C NMR of a new angiotensin I converting enzyme inhibitor, the tert ‐butylamine salt of (2 S )‐2‐[(1 S )‐1‐carbethoxybutylamino]‐1‐oxopropyl‐(2 S , 3a S , 7a S ) perhydroindole‐2‐carboxylic acid (perindopril)
Author(s) -
Platzer N.,
Bouchet J. P.,
Volland J. P.
Publication year - 1988
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260260405
Subject(s) - chemistry , proton nmr , stereochemistry , amide , carbon 13 nmr , fluorine 19 nmr , nuclear magnetic resonance spectroscopy , organic chemistry
Perindopril, a potent inhibitor of angiotensin I converting enzyme, was studied by 1 H NMR and 13 C NMR in various solvents and at various temperatures. The cis and trans conformations of the amide bond were assigned. The conformations of the perhydroindole skeleton rings were studied by 1 H NMR.