Structural and conformational analysis by  1 H NMR and  13 C NMR of a new angiotensin I converting enzyme inhibitor, the  tert ‐butylamine salt of (2 S )‐2‐[(1 S )‐1‐carbethoxybutylamino]‐1‐oxopropyl‐(2 S , 3a S , 7a S ) perhydroindole‐2‐carboxylic acid (perindopril) | Zendy

Platzer N. | Zendy; Bouchet J. P. | Zendy; Volland J. P. | Zendy

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Structural and conformational analysis by 1 H NMR and 13 C NMR of a new angiotensin I converting enzyme inhibitor, the tert ‐butylamine salt of (2 S )‐2‐[(1 S )‐1‐carbethoxybutylamino]‐1‐oxopropyl‐(2 S , 3a S , 7a S ) perhydroindole‐2‐carboxylic acid (perindopril)

Author(s) -

Platzer N.,

Bouchet J. P.,

Volland J. P.

Publication year - 1988

Publication title -

magnetic resonance in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 72

eISSN - 1097-458X

pISSN - 0749-1581

DOI - 10.1002/mrc.1260260405

Subject(s) - chemistry , proton nmr , stereochemistry , amide , carbon 13 nmr , fluorine 19 nmr , nuclear magnetic resonance spectroscopy , organic chemistry

Perindopril, a potent inhibitor of angiotensin I converting enzyme, was studied by 1 H NMR and 13 C NMR in various solvents and at various temperatures. The cis and trans conformations of the amide bond were assigned. The conformations of the perhydroindole skeleton rings were studied by 1 H NMR.

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