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Two‐dimensional NMR analysis of himachalol and its correlation with other sesquiterpenoids of the himachalane series
Author(s) -
Prakash Om,
Roy Raja,
Kulshreshtha D. K.
Publication year - 1988
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260260112
Subject(s) - heteronuclear molecule , chemistry , transverse relaxation optimized spectroscopy , chemical shift , carbon 13 nmr satellite , two dimensional nuclear magnetic resonance spectroscopy , fluorine 19 nmr , nuclear magnetic resonance spectroscopy , nuclear overhauser effect , coupling constant , dept , proton nmr , carbon 13 nmr , decoupling (probability) , nuclear magnetic resonance , stereochemistry , computational chemistry , physics , particle physics , control engineering , engineering
High‐field 1 H NMR studies of himachalol (1) have been carried out by two‐dimensional NMR methods. The stereochemical aspects of this molecule were studied through the application of stereospecific coupling constants, the nuclear Overhauser effect and lanthanide‐induced chemical shifts. Complete and unambiguous 13 C chemical shift assignments of 1 have been made for the first time by using two‐dimensional heteronuclear ( 1 H 13 C) correlation NMR spectroscopy, DEPT, broad‐band proton decoupling and selective heteronuclear spin decoupling 13 C NMR methods. Complete 13 C chemical shift assignments of isocentdarol, centdarol and centdarone have also been made using some of the above techniques and their stereostructures have been corrected.