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Modulation of methylene carbon response intensity in long‐range heteronuclear 2D NMR chemical shift correlation spectra
Author(s) -
Salazar Miguel,
Zektzer Andrew S.,
Martin Gary E.
Publication year - 1988
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260260107
Subject(s) - heteronuclear molecule , chemistry , methylene , chemical shift , spectral line , protonation , nuclear magnetic resonance , pulse sequence , two dimensional nuclear magnetic resonance spectroscopy , analytical chemistry (journal) , nuclear magnetic resonance spectroscopy , stereochemistry , organic chemistry , physics , ion , quantum mechanics
Several recent papers have dealt with the modulation of protonated carbon response intensities in long‐range heteronuclear 2D NMR chemical shift correlation spectra. Expressions describing the one‐bond modulation of the response intensity of the C‐3 methylene resonance of 6,7‐dimethoxy‐3,4‐dihydroisoquinoline, and the decoupling of this modulation afforded by a BIRD pulse located midway through the Δ 2 refocusing delay, are presented with experimental confirmation. Long‐range response intensities are related to the conventional heteronuclear chemical shift correlation spectrum optimized for transfer from the directly attached proton.