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Two‐dimensional 1 H and 13 C‐NMR spectra of 5‐(2‐dimethylaminoethoxy)‐7‐oxo‐7 H ‐benzo[ c ]fluorene, its precursor and metabolite
Author(s) -
Lyčka Antonin,
Jirman Josef,
Nobilis Milan,
Kvasničková Eva,
Hais Ivo M.
Publication year - 1987
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260251207
Subject(s) - chemistry , fluorene , spectral line , nmr spectra database , metabolite , nuclear magnetic resonance spectroscopy , stereochemistry , organic chemistry , physics , biochemistry , polymer , astronomy
The 1 H and 13 C chemical shifts in 5‐(2‐dimethylaminoethoxy)‐7‐oxo‐7 H ‐benzo[ c ]fluorene (1) and 5‐hydroxy‐7‐oxo‐7 H ‐benzo[ c ]fluorene (2) were assigned using H,H‐COSY, H,C‐COSY and selective INEPT spectra. It was found that the main phenolic metabolite of 1 and its hydrochloride corresponds to 9‐hydroxy‐5‐(2‐dimethylaminoethoxy)‐7‐oxo‐7 H ‐benzo[ c ]fluorene (3).