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Application of two‐dimensional dipolar exchange spectroscopy with multiple mixing periods
Author(s) -
Meyerhoff Dieter J.,
Nunlist Rudi,
O'Connell John F.
Publication year - 1987
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260251003
Subject(s) - chemistry , mixing (physics) , pulse sequence , two dimensional nuclear magnetic resonance spectroscopy , dipole , sequence (biology) , molecule , spectroscopy , nuclear magnetic resonance spectroscopy , analytical chemistry (journal) , chemical physics , nuclear magnetic resonance , stereochemistry , chromatography , organic chemistry , physics , biochemistry , quantum mechanics
A NOESY‐type experiment with multiple mixing periods and acquisitions within a single pulse sequence was used to obtain a complete NOE correlation map of a small organic molecule. Incorporating multiple mixing periods and acquisitions into a single sequence can eliminate the need for repeating NOESY experiments with different mixing periods to observe dipolar exchange of considerably different rates or to determine exchange rates. The sequence has been applied to the molecular structure elucidation of cis ‐8a‐vinyloctahydro‐3 H ‐2‐benzopyran‐3,7‐dione, a small organic molecule where the use of a single mixing period does not reveal all protons undergoing dipolar exchange.