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Assignment of carbonyl groups and sequence analysis in peptides by inverse correlation using long‐range couplings
Author(s) -
Bermel Wolfgang,
Griesinger Christian,
Kessler Horst,
Wagner Klaus
Publication year - 1987
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260250410
Subject(s) - heteronuclear molecule , chemistry , inverse , sequence (biology) , range (aeronautics) , stereochemistry , pulse sequence , peptide , amino acid , computational chemistry , nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , biochemistry , materials science , geometry , mathematics , physics , composite material
Inverse heteronuclear shift correlation via long‐range coupling to the carbonyl carbons of the cyclic hexapeptide cyclo(‐Phe 11 ‐Thr10‐Aia9‐Trp8‐Phe/‐D‐Pro6‐) allows the sequential assignment of the amino acids. This experiment has a higher sensitivity than the conventional COLOC sequence.