Premium
Long‐range 1 H coupling interactions: Identification of different pathways by 2D NMR δ—δ correlated spectroscopy. Applications in structural analysis
Author(s) -
Platzer N.,
Goasdoue N.,
Davoust D.
Publication year - 1987
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260250408
Subject(s) - chemistry , trimer , nuclear magnetic resonance spectroscopy , two dimensional nuclear magnetic resonance spectroscopy , spectroscopy , j coupling , crystallography , computational chemistry , stereochemistry , coupling (piping) , organic chemistry , dimer , physics , quantum mechanics , mechanical engineering , engineering
The simplest methods of 2D δ‐δ correlated spectroscopy (COSY and COSY LR) allow the easy observation of long‐range coupling interactions. It is shown how these methods can lead to the discrimination between different pathways across single bonds: 4 J through coplanar or gauche arrangement of the bonds and 5 J through a zig‐zag pathway or bond proximity. Applications to configurational and conformational analysis of polycyclic compounds, a trimer of isophorone, two natural terpenoids (carotol and daucol) and four steroids, are presented.