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Structural Studies of Hydroxylated D ‐homo‐5α‐androstanes by 1 H NMR decoupling difference techniques
Author(s) -
Campbell Sheelagh A.,
Crabb Trevor A.,
Williams Roger O.
Publication year - 1986
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260240913
Subject(s) - chemistry , decoupling (probability) , chemical shift , steroid , significant difference , stereochemistry , biochemistry , medicine , control engineering , hormone , engineering
1 H NMR chemical shifts of thirteen D‐homo‐5α‐androstan‐17a‐ones have been determined by decoupling difference techniques. Shift changes, primarily of the H‐8, H‐9 and H‐14 protons, produced by the introduction of hydroxy groups in the steroid have been shown to be of diagnostic importance.