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Carbon‐13 NMR of β‐lactam antibiotics and related compounds
Author(s) -
Branch S. K.,
Casy A. F.,
Lipczynski A.,
Ominde E. M. A.
Publication year - 1986
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260240602
Subject(s) - chemistry , cephalosporin , penicillin , benzylpenicillin , antibiotics , lactam , cephalosporin antibiotic , cephalosporin c , carbon 13 nmr , stereochemistry , computational chemistry , biochemistry
The 13 C NMR features of most β‐lactam antibiotics of the penicillin and cephalosporin groups in clinical use are presented and reviewed. Data on precursor and breakdown products are included in the survey, with particular reference to benzylpenicillin. Penicillin and cephalosporin spectra are discussed, and points of similarity and difference emphasized. The potential of the data for solving problems of analysis, stability, degradation and biological structure–activity relationships is summarized.