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13 C and 1 H NMR spectral studies of some piperidin‐4‐one oximes
Author(s) -
Pandiarajan K.,
Mohan R. T. Sabapathy,
Hasan Misbah Ul
Publication year - 1986
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260240409
Subject(s) - chemistry , chemical shift , oxime , cyclohexane conformation , nmr spectra database , carbon 13 nmr , stereochemistry , spectral line , proton nmr , nuclear magnetic resonance spectroscopy , medicinal chemistry , organic chemistry , molecule , hydrogen bond , physics , astronomy
13 C NMR spectra have been recorded for eleven piperidin‐4‐one oximes and for seven of them 1 H NMR spectra have been recorded at 270 MHz. The effect of oximation on the NMR chemical shitts is discussed. The conformations of the oximes are also discussed, based on the observed chemical shifts. Although several oximes appear to adopt a chair conformation, in the same manner as the corresponding ketones, the oximes of 3,5‐dimethyl‐2,6‐diarylpiperidin‐4‐ones with cis ‐methyl groups seem to adopt an asymmetric non‐chair conformation. Analysis of the chemical shifts of cis ‐2,6‐dimethylcyclohexanone oxime suggests that this compound also exists in a non‐chair conformation, and not in a chair conformation with two axial methyl groups as suggested previously.