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NMR spectra and stereochemistry of 2‐(piperidin‐2‐ylmethyl)cycloalkanols
Author(s) -
Begley Michael J.,
Crabb Trevor A.,
Roch Olive G.
Publication year - 1986
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260240405
Subject(s) - chemistry , cyclohexanol , cycloalkene , stereochemistry , catalysis , medicinal chemistry , organic chemistry
2‐(Piperidin‐2‐ylmethyl)cycloalkanols have been synthesized by the reaction between 2‐picolyllithium and cycloalkene oxides, followed by catalytic hydrogenation of the resulting 2‐(pyridin‐2‐ylmethyl)cycloalkanols. The configurations of the 2‐(piperidin‐2‐yl‐methyl)cycloalkanols were assigned by comparing their 13 C and 1 H NMR parameters with those of 2‐(piperidin‐2‐ylmethyl)cyclohexanols of known (x‐ray) configuration.