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Studies on the conformations in solution of 5β‐steroids having different side chains by 13 C NMR spectroscopy
Author(s) -
Seldes A. M.,
Deluca M. E.,
Gros E. G.
Publication year - 1986
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260240302
Subject(s) - chemistry , side chain , steric effects , conformational isomerism , nuclear magnetic resonance spectroscopy , chemical shift , nmr spectra database , spectroscopy , computational chemistry , stereochemistry , spectral line , crystallography , organic chemistry , molecule , polymer , physics , quantum mechanics , astronomy
13 C NMR spectra for 23 3‐substituted‐5β‐steroidal derivatives have been obtained and individual resonances assigned. The different chemical shifts due to conformational and side chain changes are rationalized in terms of steric interactions. From these results a preferred is conformer is proposed for the cholanoic acid side chain derivatives in solution.