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13 C NMR spectra of wyosine, a hypermodified nucleoside of transfer RNAs, and related compounds
Author(s) -
Golankiewicz Bożenna,
Folkman Wojciech
Publication year - 1985
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260231108
Subject(s) - chemistry , nucleoside , chemical shift , tricyclic , stereochemistry , conformational isomerism , moiety , population , nmr spectra database , nuclear magnetic resonance spectroscopy , methylation , purine , proton nmr , nucleoside analogue , carbon 13 nmr , spectral line , organic chemistry , dna , biochemistry , molecule , demography , sociology , enzyme , physics , astronomy
Complete 13 C NMR spectral assignments were made for wyosine, 4,9‐dihydro‐4,6‐dimethyl‐9‐oxo‐3‐(β‐D‐ribofuranosyl)imidazo [1,2‐ a ]purine, a hpermodified, fluorescent nucleoside of transfer RNAs, and its isomers methylated at N‐5 and at N‐1. The influence of the position of N ‐methylation on the 13 C chemical shifts of the tricyclic nucleoside is discussed. In relation to the parent N ‐unsubstituted compound, the most pronounced changes of chemical shifts appear in wyosime. Chemical shift data for the sugar moiety suggest that the population of the anti conformer in wyosine is higher than in the other tricyclic nucleosides.