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ESR of cation radicals of phenothiazine derivatives
Author(s) -
Motten Ann G.,
Chignell Colin F.
Publication year - 1985
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260231010
Subject(s) - phenothiazine , promazine , chemistry , promethazine , hyperfine structure , radical , electron paramagnetic resonance , solvent , photochemistry , aqueous solution , chlorpromazine , organic chemistry , nuclear magnetic resonance , medicine , physics , quantum mechanics , anesthesia , pharmacology , endocrinology
Phenothiazines are of interest as model heterocyclic compounds and also as pharmacological agents with a wide spectrum of biological activities. Cation radicals derived from six phenothiazine derivatives including phenothiazine, 2‐chlorophenothiazine, promazine, chlorpromazine, promethazine and trimeprazine have been studied in aqueous solution by electron spin resonance. Their high‐resolution electron spin resonance spectra have been fully analysed, and hyperfine splitting parameters have been compared with those obtained in other solvent systems where available. Previously undetected hyperfine splittings of about 0.2–0.4 G from γ‐protons on the alkyl chain were observed for promazine, promethazine and, possibly, chlorpromazine.