Conformation‐activity relationships in diethylmethyl‐2‐[ p ‐( o ‐alkyloxy‐benzamido)benzoyloxy]ethylammonium bromides in solution as detected by one‐ and two‐dimensional 1 H NMR spectroscopy

The relative conformation of the aromatic rings and the amide bridge of a series of diethylmethyl‐2‐[ p ‐( o ‐alkyloxybenzamido)benzoyloxy]ethylammonium bromides has been established by a combined analysis of non‐selective, single‐selective and double‐selective pulse experiments. Relevant details of the main conformation adopted in solution by the alkyloxy and the diethylmethyl‐2‐benzoylosyethylammonium side‐chains have been obtained by 1 H{ 1 H} NOE and 1 H two‐dimensional NMR analysis. Molecular Dreiding models were used as a basis of comparison.