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1 H NMR and IR spectra of antitumour anthracyclines: Effect of the substitution pattern on the chemical shift values of the phenolic protons and on IR absorptions of the quinone system
Author(s) -
Vigevani Aristide,
Ballabio Marzia,
Gandini Elena,
Penco Sergio
Publication year - 1985
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260230513
Subject(s) - chemistry , daunorubicin , quinone , chemical shift , stereochemistry , doxorubicin , anthracycline , carbon 13 nmr , nmr spectra database , proton nmr , spectral line , chemotherapy , medicine , physics , surgery , cancer , astronomy , breast cancer
Abstract 1 H NMR and IR data of numerous natural and synthetic analogues of daunorubicin and doxorubicin, anthracycline antibiotics successfully used in the clinical treatment of human tumours, have been recorded. The chemical shift values of the phenolic protons of approximately 130 compounds are reviewed and discussed with the aim of establishing a relationship between δ values and structural features. The IR absorptions of the quinone system in the region 1560–1680 cm −1 are also examined.