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Unequivocal total assignment of 13 C and 1 H NMR spectra of some pyrido[1,2‐ a ]pyrimidine derivatives by 2D‐NMR
Author(s) -
Suri Krishan A.,
Suri Om P.,
Amina Musarat,
Wakhloo Basant P.,
Satti Naresh K.
Publication year - 2003
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1240
Subject(s) - chemistry , heteronuclear molecule , heteronuclear single quantum coherence spectroscopy , pyrimidine , carbon 13 nmr satellite , nmr spectra database , protonation , carbon 13 nmr , two dimensional nuclear magnetic resonance spectroscopy , spectral line , stereochemistry , nuclear magnetic resonance spectroscopy , proton nmr , fluorine 19 nmr , computational chemistry , organic chemistry , ion , physics , astronomy
We report the total assignments of the 13 C and 1 H NMR spectra of some 4‐methyl‐2‐oxo‐(2 H )‐pyrido[1,2‐ a ]pyrimidine and 2‐methyl‐4‐oxo‐(4 H )‐pyrido[1,2‐ a ]pyrimidine derivatives. The products were characterized by 1 H and 13 C NMR and reported data for similar compounds. No comparative data for the two sets of isomeric compounds with respect to 13 C and 1 H NMR have been reported to date. We made some detailed studies of the 2D NMR spectra of these compounds and observed that assignments made for non‐protonated carbon atoms by us and those reported in the literature for similar compounds need correction. The revised assignments were made on the basis of heteronuclear single quantum correlation (HSQC) and heteronuclear multiple bond correlation (HMBC) techniques. Copyright © 2003 John Wiley & Sons, Ltd.