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Isolation and characterization of a Tie2 kinase inhibitory sulfated triterpenoid from a green alga of the Tuemoya genus: complete assignment of the 1 H and 13 C spectra of a sulfated triterpenoid Tie2 kinase inhibitor
Author(s) -
Clement Jason A.,
Zhou BingNan,
Johnson Randall K.,
Kingston David G. I.
Publication year - 2003
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1228
Subject(s) - chemistry , triterpenoid , sulfation , stereochemistry , fractionation , enzyme , two dimensional nuclear magnetic resonance spectroscopy , biochemistry , chromatography
Bioassay‐guided fractionation of an extract of a Tuemoya sp., using an assay for inhibitors of the enzyme Tie2 kinase, afforded a mixture of the sulfated cycloartanol triterpenoids 1 and 2. We report the full 1 H and 13 C NMR spectral assignments for 1 and the 13 C NMR spectral assignments for 2. Copyright © 2003 John Wiley & Sons, Ltd.