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Flow injection analysis NMR (FIA–NMR): a novel flow NMR technique that complements LC–NMR and direct injection NMR (DI–NMR)
Author(s) -
Keifer Paul A.
Publication year - 2003
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1206
Subject(s) - chemistry , fluorine 19 nmr , nuclear magnetic resonance spectroscopy , proton nmr , carbon 13 nmr , two dimensional nuclear magnetic resonance spectroscopy , carbon 13 nmr satellite , flow injection analysis , analytical chemistry (journal) , chromatography , organic chemistry , stereochemistry , detection limit
Details of a new flow NMR technique, flow injection analysis NMR (FIA–NMR), are presented for the first time. This method blends some aspects of both liquid chromatography–NMR and direct injection NMR, and complements both. FIA‐NMR is shown to be useful as an analytical technique, especially for repetitive analyses, and may also prove useful in the analysis of combinatorial chemistry libraries. The feasibility of FIA‐NMR is demonstrated by the quantitative analysis of an over‐the‐counter pharmaceutical. Copyright © 2003 John Wiley & Sons, Ltd.