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Complete structural and spectral assignment of oxoisoaporphines by HMQC and HMBC experiments
Author(s) -
SobarzoSánchez Eduardo,
Cassels Bruce K.,
Jullian Carolina,
Castedo Luis
Publication year - 2003
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1177
Subject(s) - chemistry , sulfuric acid , hydrochloride , stereochemistry , carbon 13 nmr , spectral analysis , nmr spectra database , proton nmr , medicinal chemistry , spectral line , organic chemistry , spectroscopy , physics , quantum mechanics , astronomy
The oxoisoaporphines 2,3‐dihydro‐7 H ‐dibenzo[ de,h ]quinolin‐7‐one, 2,3‐dihydro‐5‐methoxy‐7 H ‐dibenzo [ de,h ] quinolin‐7‐one, 5‐methoxy‐6‐hydroxy‐2,3‐dihydro‐7 H ‐dibenzo[ de,h ]quinolin‐7‐one, 5,6‐dimethoxy‐2,3‐dihydro‐7 H ‐dibenzo[ de,h ]quinolin‐7‐one and 5,6‐methylenedi‐oxy‐2,3‐dihydro‐7 H ‐dibenzo[ de,h ]quinolin‐7‐one were prepared by cyclization of phenylethylaminophthalides with polyphosphoric acid or by treating 1‐(2‐carboxyphenyl)‐3,4‐dihydroisoquinoline hydrochloride with sulfuric acid at 0 °C. The structures were confirmed and 1 H and 13 C NMR spectra were completely assigned using a combination of one‐ and two‐dimensional NMR techniques. Copyright © 2003 John Wiley & Sons, Ltd.