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A new technique for differentiating between 2 J (C,H) and 3/4 J (C,H) connectivities
Author(s) -
Sprang Thomas,
Bigler Peter
Publication year - 2003
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1154
Subject(s) - chemistry , spectrum (functional analysis) , spectral line , pulse sequence , analytical chemistry (journal) , sensitivity (control systems) , stereochemistry , nuclear magnetic resonance , physics , quantum mechanics , chromatography , electronic engineering , engineering
We present a new pulse sequence that yields two simultaneously detected types of long‐range correlation spectra. The one spectrum is to show all n J (C,H) connectivities and the other is to show exclusively 2 J (C,H) connectivities. The method is demonstrated by using strychnine as a test sample. A comparison with HMBC shows that the 2 J (C,H)/ n J (C,H) experiment supplies a n J (C,H) spectrum that is of equal standard with regard to sensitivity and spectral information. The additional 2 J (C,H) spectrum allows the disentanglement of 2 J (C,H) and n J (C,H) signals ( n > 2) in HMBC type spectra, which greatly simplifies signal assignment and structure elucidation in general. Copyright © 2003 John Wiley & Sons, Ltd.