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Functionalization of PAMAM dendrimers with nitronyl nitroxide radicals as models for the outer‐sphere relaxation in dentritic potential MRI contrast agents
Author(s) -
Francese Giancarlo,
Dunand Frank A.,
Loosli Claudia,
Merbach André E.,
Decurtins Silvio
Publication year - 2003
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1151
Subject(s) - chemistry , dendrimer , radical , nitroxide mediated radical polymerization , electron paramagnetic resonance , relaxation (psychology) , surface modification , inner sphere electron transfer , nuclear magnetic resonance , polymer chemistry , polymer , organic chemistry , monomer , radical polymerization , psychology , social psychology , physics , ion
Abstract PAMAM dendrimers functionalized with nitronyl nitroxide radicals were characterized. Quantitative determination of substitution with radicals was performed using EPR and electrochemical methods. The study of the 1 H NMR relaxation of the surrounding water showed how the outer‐sphere contribution to the relaxivity may be limited by the presence of the dendrimer core. Copyright © 2003 John Wiley & Sons, Ltd.