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NMR studies on 1,2‐dihydro‐2‐(4‐aminophenyl)‐4‐[4‐(4‐aminophenoxy)‐4‐phenyl]‐(2 H )phthalazin‐1‐one
Author(s) -
Wang Tianzhi,
Cheng Lin,
Zhang Tao,
Yuan Hanzhen,
Mao Shizhen
Publication year - 2002
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1087
Subject(s) - chemistry , heteronuclear molecule , homonuclear molecule , nuclear magnetic resonance spectroscopy , spectroscopy , phthalazine , two dimensional nuclear magnetic resonance spectroscopy , nuclear overhauser effect , ether , crystallography , stereochemistry , medicinal chemistry , molecule , organic chemistry , physics , quantum mechanics
An unsymmetrical heterocyclic diamine, 1,2‐dihydro‐2‐(4‐aminophenyl)‐4‐[4‐(4‐aminophenoxy)‐4‐phenyl]‐(2 H )phthalazin‐1‐one, was synthesized. Its 1 H and 13 C NMR spectra were completely assigned by utilizing the two‐dimensional heteronuclear 13 C– 1 H multiple‐bond coherence (HMBC) spectroscopy, and heteronuclear 13 C– 1 H one‐bond correlation spectroscopy, homonuclear shift correlation spectroscopy (H,H‐COSY) and rotating frame Overhauser enhancement spectroscopy (ROESY). The structure of the compound was shown to be the phthalazinone rather than the phthalazine ether from cross peaks and chemical shifts of the protons. Copyright © 2002 John Wiley & Sons, Ltd.