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Four new ursane‐type saponins from Morina nepalensis var. alba
Author(s) -
Teng Rong Wei,
Xie Hong Yan,
Wang De Zu,
Yang Chong Ren
Publication year - 2002
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1060
Subject(s) - chemistry , saponin , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , carbon 13 nmr , medicine , alternative medicine , pathology
Four new ursane‐type saponins, monepalosides C–F, together with a known saponin, mazusaponin II, were isolated from Morina nepalensis var. alba Hand.‐Mazz. Their structures were determined to be 3‐ O ‐α‐ L ‐arabinopyranosyl‐(1 → 3)‐&[alpha;‐ L ‐rhamnopyranosyl‐(1 → 2)]‐α‐ L ‐arabinopyranosylpomolic acid 28‐ O ‐β‐ D ‐glucopyranosyl‐(1 → 6)‐β‐ D ‐glucopyranoside (monepaloside C, 1 ), 3‐ O ‐α‐ L ‐arabinopyranosyl‐(1 → 3)‐&[alpha;‐ L ‐rhamnopyranosyl‐(1 → 2)]‐β‐ D ‐xylopyranosylpomolic acid 28‐ O ‐β‐ D ‐glucopyranosyl‐(1 → 6)‐β‐ D ‐glucopyranoside (monepaloside D, 2 ), 3‐ O ‐α‐ L ‐arabinopyranosyl‐(1 → 3)‐&[beta;‐ D ‐glucopyranosy‐(1 → 2)]‐α‐ L ‐arabinopyranosylpomolic acid 28‐ O ‐β‐ D ‐glucopyranosyl‐(1 → 6)‐β‐ D ‐glucopyranoside (monepaloside E, 3 ) and 3‐ O ‐β‐ D ‐xylopyranosylpomolic acid 28‐ O ‐β‐ D ‐glucopyranoside (monepaloside F, 4 ) on the basis of chemical and spectroscopic evidence. 2D NMR techniques, including 1 H– 1 H COSY, HMQC, 2D HMQC‐TOCSY, HMBC and ROESY, and selective excitation experiments, including SELTOCSY and SELNOESY, were utilized in the structure elucidation and complete assignments of 1 H and 13 C NMR spectra. Copyright © 2002 John Wiley & Sons, Ltd.