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Complete assignment of the NMR spectra of [ D ‐Leu 1 ]‐microcystin‐LR and analysis of its solution structure
Author(s) -
Schripsema Jan,
Dagnino Denise
Publication year - 2002
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1059
Subject(s) - microcystin , chemistry , microcystis aeruginosa , amide , proton nmr , nmr spectra database , strain (injury) , microcystis , stereochemistry , spectral line , cyanobacteria , organic chemistry , bacteria , medicine , genetics , astronomy , biology , physics
[ D ‐Leu 1 ]‐microcystin‐LR is a recently discovered microcystin. We report the isolation of this microcystin analogue from a Microcystis aeruginosa strain isolated from the Lagoa de Iquipari, Rio de Janeiro, Brazil. The 1 H and 13 C NMR spectra were completely assigned in both MeOH‐ d 4 and DMSO‐ d 6 . Further, the solution structure of this compound was investigated with the use of two‐dimensional NMR and the amide proton temperature dependence, and was compared with those of its analogs, microcystin‐RR and microcystin‐LR. Copyright © 2002 John Wiley & Sons, Ltd.