1 H and  13 C NMR study of 2‐hydroxyglutaric acid and its lactone | Zendy

Bal Dominika | Zendy; GryffKeller Adam | Zendy

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1 H and 13 C NMR study of 2‐hydroxyglutaric acid and its lactone

Author(s) -

Bal Dominika,

GryffKeller Adam

Publication year - 2002

Publication title -

magnetic resonance in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 72

eISSN - 1097-458X

pISSN - 0749-1581

DOI - 10.1002/mrc.1053

Subject(s) - chemistry , lactone , metabolite , chemical shift , coupling constant , nuclear magnetic resonance spectroscopy , analytical chemistry (journal) , computational chemistry , nuclear magnetic resonance , organic chemistry , biochemistry , physics , particle physics

Determination of the level and absolute configuration of 2‐hydroxyglutaric acid in a patient's urine is a method of diagnosing two metabolic diseases. Such a determination can be done with the aid of NMR spectroscopic methods. In this paper the careful interpretation of 1 H and 13 C NMR spectra of this metabolite and its lactone measured under conditions used in biomedical assays is reported. The 1 H chemical shifts and spin–spin coupling constants were derived using the total lineshape analysis method. Copyright © 2002 John Wiley & Sons, Ltd.

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