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An NMR tool for cyclodextrin selection in enantiomeric resolution by high‐performance liquid chromatography
Author(s) -
Laverde Antonio,
da Conceição Gelson J. A.,
Queiroz Sonia C. N.,
Fujiwara Fred Y.,
Marsaioli Anita J.
Publication year - 2002
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1043
Subject(s) - chemistry , enantiomer , cyclohexanone , cyclodextrin , chromatography , resolution (logic) , computational chemistry , organic chemistry , catalysis , artificial intelligence , computer science
Complexation‐induced chemical shifts and diffusion coefficients (HR‐DOSY) of enantiomers with native and derivatized cyclodextrins were used for calculations of the apparent binding constants of three cyclohexanone inclusion complexes. Correlations between these data and high‐performance liquid chromatography were established, revealing that this approach can be applied as an alternative method to predict enantiomeric discrimination. Copyright © 2002 John Wiley & Sons, Ltd.

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