Open AccessB‐Cell lymphoproliferative disorder not associated with Epstein‐Barr Virus in a child with relapsed acute lymphoblastic leukemia
Author(s) -
Lehrnbecher Thomas,
Trusen Andreas,
Deinlein Frank,
Höcht Burkhard,
Marx Alexander,
Kühl Joachim
Publication year - 2003
Publication title -
medical and pediatric oncology
Language(s) - English
Resource type - Journals
eISSN - 1096-911X
pISSN - 0098-1532
DOI - 10.1002/mpo.10202
Subject(s) - medicine , discontinuation , chemotherapy , epstein–barr virus , lymphoblastic leukemia , lymphoma , virus , lymphoproliferative disorders , acute lymphocytic leukemia , immunology , leukemia , oncology , pediatrics
Abstract Lymphoproliferative disorder (LPD) is described in only a few children receiving chemotherapy for cancer. In all of them, an association between LPD and EBV (Epstein‐Barr Virus) was found. We report on a patient who developed LPD not associated with EBV while receiving chemotherapy for relapsed acute lymphoblastic leukemia (ALL). Despite discontinuation of chemotherapy, administration of intravenous immunoglobulins and surgery the patient died. Growing experience with this disorder may allow better treatment options in the future and will show whether LPD not associated with EBV requires different therapeutic strategies. Med Pediatr Oncol 2003;40:13–17, © 2003 Wiley‐Liss, Inc.