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Technical Note: Single‐pulse beam characterization for FLASH‐RT using optical imaging in a water tank
Author(s) -
Ashraf M. Ramish,
Rahman Mahbubur,
Zhang Rongxiao,
Cao Xu,
Williams Benjamin B.,
Hoopes P. Jack,
Gladstone David J.,
Pogue Brian W.,
Bruza Petr
Publication year - 2021
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1002/mp.14843
Subject(s) - dosimetry , linear particle accelerator , optics , materials science , dosimeter , imaging phantom , isocenter , beam (structure) , truebeam , radioluminescence , nuclear medicine , physics , detector , medicine , scintillator
Purpose High dose rate conditions, coupled with problems related to small field dosimetry, make dose characterization for FLASH‐RT challenging. Most conventional dosimeters show significant dependence on dose rate at ultra‐high dose rate conditions or fail to provide sufficiently fast temporal data for pulse to pulse dosimetry. Here fast 2D imaging of radioluminescence from a water and quinine phantom was tested for dosimetry of individual 4 μs linac pulses. Methods A modified clinical linac delivered an electron FLASH beam of >50 Gy/s to clinical isocenter. This modification removed the x‐ray target and flattening filter, leading to a beam that was symmetric and gaussian, as verified with GafChromic EBT‐XD film. Lateral projected 2D dose distributions for each linac pulse were imaged in a quinine‐doped water tank using a gated intensified camera, and an inverse Abel transform reconstruction provided 3D images for on‐axis depth dose values. A total of 20 pulses were delivered with a 10 MeV, 1.5 cm circular beam, and beam with jaws wide open (40 × 40 cm 2 ), and a 3D dose distribution was recovered for each pulse. Beam output was analyzed on a pulse by pulse basis. Results The R p , D max , and the R 50 measured with film and optical methods agreed to within 1 mm for the 1.5 cm circular beam and the beam with jaws wide open. Cross beam profiles for both beams agreed with film data with >95% passing rate (2%/2 mm gamma criteria). The optical central axis depth dose agreed with film data, except for near the surface. A temporal pulse analysis revealed a ramp‐up period where the dose per pulse increased for the first few pulses and then stabilized. Conclusions Optical imaging of radioluminescence was presented as a valuable tool for establishing a baseline for the recently initiated electron FLASH beam at our institution.