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Improving contrast and spatial resolution in crystal analyzer‐based x‐ray dark‐field imaging: Theoretical considerations and experimental demonstration
Author(s) -
Ando Masami,
Nakao Yuki,
Jin Ge,
Sugiyama Hiroshi,
Sunaguchi Naoki,
Sung Yongjin,
Suzuki Yoshifumi,
Sun Yong,
Tanimoto Michio,
Kawashima Katsuhiro,
Yuasa Tetsuya,
Mori Kensaku,
Ichihara Shu,
Gupta Rajiv
Publication year - 2020
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1002/mp.14442
Subject(s) - collimator , image resolution , optics , resolution (logic) , collimated light , contrast (vision) , monochromator , spectrum analyzer , mammography , physics , materials science , computer science , breast cancer , artificial intelligence , medicine , cancer , wavelength , laser
Purpose This paper describes and experimentally validates a methodology for improving contrast and spatial resolution of the x‐ray dark‐field imaging (XDFI) by cutting the monochromator‐collimator asymmetrically and thinning the Laue angle analyzer. Methods We measure the spatial resolution of our XDFI setup using a test object consisting of wolfram tungsten meshes and compare it with the theoretical prediction. Using x‐ray dark‐field computed tomography of breast cancer specimens (lobular carcinoma in situ), we demonstrate that the resolution of XDFI is sufficient for histopathologic analysis. Results Our experimental results show that the overall spatial resolution of XDFI can be improved by approximately a factor of 2 when these modifications are implemented. The reconstructed images of breast cancer specimens provide sufficient details for radiologic histopathology. Conclusions By cutting the monochromator‐collimator and thinning the Laue angle analyzer, XDFI can achieve the resolution sufficient for radiologic histopathology.