Premium
Deformable phantoms of the prostatic urinary tract for urodynamic investigations
Author(s) -
Ishii Takuro,
Ho Chung Kit,
Nahas Hassan,
Yiu Billy Y. S.,
Chee Adrian J. Y.,
Yu Alfred C. H.
Publication year - 2019
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1002/mp.13558
Subject(s) - urethra , imaging phantom , biomedical engineering , prostatic urethra , medicine , materials science , anatomy , nuclear medicine , prostate , cancer
Purpose Assessment of urethral dynamics is clinically regarded to be important in analyzing the functional impact of pathological features like urethral obstruction, albeit it is difficult to perform directly in vivo . To facilitate such an assessment, urethra phantoms may serve well as investigative tools by reconstructing urethral dynamics based on anthropomorphic factors. Here, our aim is to design a new class of anatomically realistic, deformable urethra phantoms that can simulate the geometric, mechanical, and hydrodynamic characteristics of the male prostatic urethra. Methods A new lost‐core tube casting protocol was devised. It first involved the drafting of urethra geometry in computer‐aided design software. Next, 3D printing was used to fabricate the urethra geometry and an outer mold. These parts were then used to cast a urinary tract using a polyvinyl alcohol ( PVA )‐based material (with 26.6 ± 4.0 kP a Young's elastic modulus). After forming a surrounding tissue‐mimicking slab using an agar–gelatin mixture (with 17.4 ± 3.4 kP a Young's modulus), the completed urethra phantom was connected to a flow circuit that simulates voiding. To assess the fabricated phantoms' morphology, ultrasound imaging was performed over different planes. Also, color Doppler imaging was performed to visualize the flow profile within the urinary tract. Results Deformable phantoms were devised for the normal urethra and a diseased urethra with obstruction due to benign prostatic hyperplasia ( BPH ). During voiding, the short‐axis lumen diameter at the verumontanum of the BPH ‐featured phantom (0.91 ± 0.08 mm) was significantly smaller than that for the normal phantom (2.49 ± 0.20 mm). Also, the maximum flow velocity of the BPH ‐featured phantom (59.3 ± 5.8 cm/s; without Doppler angle correction) was found to be higher than that of the normal phantom (22.7 ± 9.0 cm/s). Conclusion The fabricated phantoms were effective in simulating urethra deformation resulting from urine passage during voiding. They can be used for mechanistic studies of urethral dynamics and for the testing of urodynamic diagnostic techniques in urology.