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Multiphoton microscopy for monitoring the occurrence, metastasis and therapy of breast cancer
Author(s) -
Liu Yulan,
Yi Yu,
Li Zhen,
Li Lianhuang,
Zhan Zhenlin,
Chen Jianxin,
Zheng Liqin
Publication year - 2021
Publication title -
microwave and optical technology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 76
eISSN - 1098-2760
pISSN - 0895-2477
DOI - 10.1002/mop.32962
Subject(s) - breast cancer , medicine , malignancy , metastasis , photobleaching , cancer , breast tumor , breast cancer metastasis , oncology , pathology , medical physics , radiology , cancer metastasis , physics , fluorescence , quantum mechanics
Worldwide, the most common malignancy in women is breast cancer. At present, the gold standard for breast cancer diagnosis, namely pathological analysis, cannot reach the subcellular level, and is unable to provide more physiological information. Multiphoton microscopy (MPM) has its unique advantages, such as label‐free detection, high resolution, low damage, deep imaging depth, low photobleaching and phototoxicity, and so on, which make up for the deficiences of traditional methods. This review mainly introduces the principle of MPM and its applications in breast diseases, especially in monitoring the occurrence, progression, metastasis, and therapy response of tumor. At the same time, the performance and progress of MPM combined with nanomaterials in breast cancer treatment are summarized. Finally, we propose the clinical challenges and future research directions of MPM.