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Front Cover: Pepsin Digest of Gliadin Forms Spontaneously Amyloid‐Like Nanostructures Influencing the Expression of Selected Pro‐Inflammatory, Chemoattractant, and Apoptotic Genes in Caco‐2 Cells: Implications for Gluten‐Related Disorders
Author(s) -
Herrera Maria Georgina,
Nicoletti Francesco,
Gras Marion,
Dörfler Philipp W.,
Tonali Nicolo,
Hannappel Yvonne,
Ennen Inga,
Hütten Andreas,
Hellweg Thomas,
Lammers Karen M.,
Dodero Veronica I.
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202170040
Subject(s) - gliadin , immune system , caco 2 , gluten , enterocyte , chemistry , microbiology and biotechnology , inflammation , apoptosis , front cover , pepsin , biology , immunology , biochemistry , cell , small intestine , cover (algebra) , enzyme , mechanical engineering , engineering
Mol. Nutr. Food Res . 2021, 65 , 202100200 DOI: 10.1002/mnfr.202100200 An integral physicochemical and functional approach demonstrated that pepsin gliadin digest forms spontaneously amyloid‐type nanostructures whose interaction with the Caco‐2 enterocyte cellular model induces the expression of selected mRNAs involved in the activation of immune cells. Therefore the pathogenic role of gliadin nanostructures may be relevant for biodemical research. This is reported by Veronica I. Dodero and co‐workers in article number 2100200.